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Larvicidal effects of fungal Meroterpenoids in the control of Aedes aegypti L., the main vector of dengue and Yellow fever.

Geris R, Rodrigues-Fo E, Garcia da Silva HH, Garcia da Silva I

Instituto de Química, Universidade Federal da Bahia, Rua Barão de Geremoabo s/n, Ondina, Salvador - BA, 41950-350, Brasil. rmgeris@ufba.br

The mosquito Aedes aegypti is an increasing problem of public health, being the vector responsible for dengue and Yellow Fever in tropical and subtropical regions. The aim of this work was to determine the potential larvicidal activity of a series of meroterpenoids, compounds 1-7, previously obtained fungal secondary metabolites from Penicillium sp., against the third-instar larvae of A. aegypti. The lethal concentrations (LC(50) and LC(90)) of 1-7 were evaluated 24 h after exposure. Dehydroaustin (4) was the most active meroterpenoid in the series, with an LC(50) value of 2.9 ppm, making it an attractive natural insecticide.

Published 28 February 2008 in Chem Biodivers, 5(2): 341-5.
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