Yellow Fever Research Today is a free monthly online journal that collates and summarizes the latest research about Yellow Fever, including details on immunization, vaccines, symptoms, transmission.

Sickle Cell Anemia and Functioning Splenic Tissue: Correlation of Scintigraphic Findings and CT.

Mestre-Fusco A, Aguadé-Bruix S, Zuccarino F, Boronat-Ferrater M, Rossi S, Andreu J

From the *Nuclear Medicine Service, Hospital Vall d’Hebron, Barcelona, Spain; †Scuola di Specializzazione in Radiodiagnostica, Ospedale Universitario San Martino, Universita’ di Genova, Italy; and ‡Department of Radiology, Hospital Vall d’Hebron, Barcelona, Spain.

We report the case of a 16-year-old girl from Central Africa who was hospitalized with an acute vasoclusive crisis and lumbar pain. She had a medical history of malaria at 6 years of age, yellow fever at 14, sickle cell disease at 2, and hepatopathy by hepatitis C virus. Splenic ultrasound revealed splenic enlargement with multiple hypoechogenicity intrasplenic masses of. A standard whole-body CT showed a moderate splenomegaly with splenic nodular masses with high density that suggested splenomas. Technetium-99m heat-damaged red blood cells showed multiple focal rounded masses with radiotracer activity indicating functioning intrasplenic tissue and regenerating nodules, whereas the rest of the parenchyma was nonfunctioning.

Published 22 January 2008 in Clin Nucl Med, 33(2): 137-139.
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