Yellow Fever Research Today is a free monthly online journal that collates and summarizes the latest research about Yellow Fever, including details on immunization, vaccines, symptoms, transmission.

Yellow fever vaccine-associated viscerotropic disease and death in Spain.

Doblas A, Domingo C, Bae HG, Bohórquez CL, de Ory F, Niedrig M, Mora D, Carrasco FJ, Tenorio A

Emergency and Critical Care Department, Juan Ramón Jiménez Hospital, Huelva, Spain.

Yellow fever vaccine-associated viscerotropic disease (YEL-AVD) is a recently described severe adverse event after yellow fever vaccination, and some cases have been reported in different countries [Anonymous. Effects of yellow fever and vaccination. Lancet 2001;358(9296):1907-9]. Herein we describe a YEL-AVD case in a young woman, who died after vaccination with 17D-204 strain. Clinical, serological and immunochemical analysis as well as virus detection, quantification, sequence analysis and cytokine release, were performed. Further investigations on yellow fever vaccine adverse events, and carefully analysis of the immune response elicited are important tasks for the future.

Published 16 May 2006 in J Clin Virol, 36(2): 156-8.
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